As a Science Advisor for NGUYEN TARBET LLC, Nichole takes tremendous care and pride in developing and protecting the intellectual property rights of each of our clients. Nichole prepares and prosecutes patent applications, and oversees national and international patent portfolios for our clients. She routinely analyzes intellectual property portfolios and performs IP due diligence for venture capital firms, other investors, and businesses.

Nichole’s Ph.D. work focused around RNA metabolism, cellular signaling pathways, and cellular stress responses to ultimately try and unravel the regulation of cytoplasmic mRNA decay.

Nichole’s intellectual property work includes subject matter such as:

• Neurodegenerative diseases
• Inflammatory disease
• Immunotherapy
• Cancer detection and therapies
• Microbial infection detection and therapies
• Biotechnology and pharmaceuticals
• Methods for tissue regeneration and repair
• Diagnostics
• Medical devices
• Biochip platform devices
• Radiation biology
• Modified crops
• Methods for RNA and DNA detection

• University of Arizona (Ph.D., Molecular and Cellular Biology, 2019)
• Mansfield University of Pennsylvania (B.S. Biology, minor in Chemistry, Summa Cum Laude, 2013)

Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast. Eshleman, N., Lou, X., Capaldi, AP., and Buchan JR. RNA (2019)

Stress granules and ALS: A case of causation or correlation? Fernandes, N., Eshleman, N., and Buchan JR. Advances in Neurobiology. (2018)

Defects in THO/TREX-2 function cause accumulation of novel cytoplasmic mRNP granules that can be cleared by autophagy. Eshleman, N., Liu, G., McGrath, K., Parker, R. & Buchan JR. RNA. (2016)

Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1) Liu, J., Stevens, P. D., Eshleman, N. L. & Gao. J. Biol. Chem. 288, 23225-23233 (2013)